Sustainable Chemistry of Benzimidazole and its Derivatives: An Eco-Friendly Method for Producing Effective Antimicrobials

Ashutosh Pathak; Alpa Verma; Neha Singh Yadav

doi:10.67275/wsgvvr44

Authors

Ashutosh Pathak Institute Of Pharmacy, Dr. Shakuntala Misra National Rehabilitation University, Mohan Rd, Sarosa Bharosa, Lucknow, Uttar Pradesh India-226017 Author
Alpa Verma Institute Of Pharmacy, Dr. Shakuntala Misra National Rehabilitation University, Mohan Rd, Sarosa Bharosa, Lucknow, Uttar Pradesh India-226017 Author
Neha Singh Yadav Department of Intellectual Disability, Dr. Shakuntala Misra National Rehabilitation University, Mohan Rd, Sarosa Bharosa, Lucknow, Uttar Pradesh, India 226017 Author

DOI:

https://doi.org/10.67275/wsgvvr44

Keywords:

benzimidazole, antimicrobials, thiabendazole, Thin Layered Chromatography

Abstract

Certain compounds, such as benzimidazole hydrazone, have been created to evaluate their efficacy against bacteria since medical drugs containing benzimidazole and hydrating agents are significant antimicrobials. Using elemental analysis, 1H-NMR measurements, infrared radiation, and ES-MS spectrum evidence, the chemical composition of the novel produced compounds was elucidated. Following the evaluation of the synthetic chemicals, it was found that the addition of standard Schiff bases and particular substance clusters inserted beneath either benzimidazole nuclear structures along with an altered nucleus (-Cl, -NO2 , OCH3 , -Br) increases the ability to kill bacteria. Each variation performed well against Gram-positive bacteria but poorly against germs with Gram-negative DNA. Several of the recently synthesized chemicals showed modest effectiveness when tested against fungus.